Two DPhil Studentships in Electron Paramagnetic Resonance – Royal Society Funded and based at the University of Oxford
Start Date: 1st October 2018
Supervisor: Dr Alice Bowen (http://research.chem.ox.ac.uk/alice-bowen.aspx )
Applications are invited for two 4-year DPhil studentships under the supervision of Dr Alice Bowen (Royal Society-EPSRC Dorothy Hodgkin Fellow) at the Department of Chemistry (Inorganic Chemistry), Oxford University in the field of pulsed Electron Paramagnetic Resonance (EPR).
The projects in Dr Bowen’s group aim to develop and apply pulsed dipolar spectroscopy (PDS) techniques, such as double electron-electron resonance (DEER) and the relaxation induced dipolar modulation experiment (RIDME), to study novel hetero-spin labelled systems containing two or more different types of spin centre.
PDS EPR is an important technique in structural biology; dipolar interactions measured between pairs of spin centres (1.5 to ca. 10 nm apart) can be related to the distance, and in some cases orientation, between the spin centres. This distance range matches the size of many biological systems and the distance restraints determined provide information about the structure and in some cases the dynamics of the system being investigated.
The University of Oxford provides world-class facilities for research and skills training. In particular the Centre for Advanced Electron Spin Resonance located within the Department of Chemistry is a world leading facility for EPR research (http://caesr-web.chem.ox.ac.uk/home )
This project will investigate the application of optically activated spin-labels, either based on triplet states or formed by photo-switching of molecules, for distance measurements in systems containing two or more spin centres. The use of optically activated spin labels has the potential to control the complexity of the system by ‘turning-on’ or leaving off dipolar interactions within the system. New types of spin labels will be investigated in collaboration with Prof. Snorri Sigurdsson (University of Iceland; https://notendur.hi.is/snorrisi/ ) and the techniques developed as part of this project will be applied to biologically important CREB-bZIP system in collaboration with Dr Sarah Shammas (Department of Biochemistry, Oxford University;
This project will involve using model systems, containing different forms of stable radical centres including lanthanide metals synthesised in collaboration with Prof. Stephen Faulkner (Department of Chemistry, Oxford University; http://research.chem.ox.ac.uk/stephen-faulkner.aspx) to optimise experimental techniques before applying the techniques to interesting biological systems, including the p7 viroporin in collaboration with Prof. Nicole Zitzmann (Department of Biochemistry, Oxford University; https://www.bioch.ox.ac.uk/research/zitzmann ).
Applicants for both these funded, 4-year DPhil studentships should have an undergraduate or Master’s degree in a relevant discipline (e.g. Physics, Chemistry, Biochemistry, Natural Sciences etc.), an interest in simulations and experimental work, problem solving and creative thinking. No prior experience of Electron spin Resonance or other forms of spectroscopy is necessary.
The studentship funding will cover university fees (payed at current RCUK Home/EU rate) and a stipend of not less than £14,533 per annum will be funded by the Royal Society. Candidates can be of any nationality, however funding towards the university fees will only be provided up to the Home/EU rate.
One studentship is offered in association with a Crewe Scholarship at Lincoln College, Oxford (http://www.lincoln.ox.ac.uk/ ) which will cover the college fees. Lincoln College has a long established tradition of supporting graduate students; having one of the largest and the oldest Middle Common Room (MCR) in Oxford. The college also has a large stock of graduate housing close to the city centre.
The other studentship is offered with a funded position at Jesus College, Oxford or another college of the candidates choosing. The college system in Oxford ensures that graduate students are immersed in an international and academically broad community outside of their doctoral studies.
More information can be found here:
Interested students are invited to contact email@example.com for informal discussions prior to submitting a formal application for DPhil in Inorganic Chemistry. (http://www.ox.ac.uk/admissions/graduate ).
Please quote: AB/EPR/2018 in your application form.
Application deadline: Positions will be advertised until filled but you are encouraged to apply as soon as possible.
Queries related to application process should be directed to: firstname.lastname@example.org